Tadalafil: What to know before you start

Have questions about tadalafil? You’re not alone. Tadalafil is a popular pill for erectile dysfunction and sometimes for enlarged prostate. It can work well, but a few safety checks make a big difference. Read on for plain facts about how it works, common doses, risks to watch for, and safe ways to buy it online.

How tadalafil works and typical doses

Tadalafil belongs to a group called PDE5 inhibitors. It helps blood flow to the penis when you’re sexually aroused. Most people feel effects within 30–60 minutes, and the drug can work up to 36 hours — that’s why it’s nicknamed the "weekend pill." Typical as-needed doses are 10 mg or 20 mg taken before sex. Low daily dosing (2.5–5 mg once daily) is an option for men who want more spontaneity or who have frequent sexual activity. Do not self-adjust your dose without talking to your prescriber.

How to use tadalafil safely

Common side effects include headache, flushing, indigestion, back pain and muscle aches. These usually go away within a day or two. Serious problems are rare but possible. Never take tadalafil with any nitrate medication (like nitroglycerin) — that combo can cause a dangerous drop in blood pressure. Be careful if you have heart disease, low blood pressure, or recent stroke. Men with diabetes often use tadalafil, but it’s important to check heart risk first since heart disease is common in diabetes.

If an erection lasts more than 4 hours, seek emergency care — prolonged erections can cause permanent damage. Also call a doctor if you have sudden vision loss, sudden hearing changes, or severe chest pain after taking tadalafil.

Some medicines and substances change tadalafil levels. Strong CYP3A4 inhibitors (for example certain antifungals and HIV drugs) can raise tadalafil in your blood and may require a lower dose. Alcohol and heavy drinking can increase side effects like dizziness and low blood pressure, so watch your intake.

Buying tadalafil online — practical tips

Want to buy tadalafil online? Use these rules: get a prescription from a licensed provider, choose a pharmacy with real contact details and good reviews, and avoid sites that ship without asking for a prescription. Compare prices but be wary of very cheap offers — counterfeit pills are common. Look for clear packaging, batch numbers, and shown manufacturer details. If the pharmacy won’t answer basic questions about shipping or returns, don’t order.

Generic tadalafil is widely available and usually cheaper than brand-name versions. Before ordering, check storage and shipping methods, especially if you live somewhere hot. Store pills at room temperature away from moisture and direct heat.

If you have questions specific to diabetes, heart disease, or other meds you take, talk to your doctor or pharmacist. Need more reading? Browse our related guides on safe online pharmacies and medication interactions to make a smart, safe choice.